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Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close
Thats a pretty striking difference
doi: 10.3389/fcell.2024.1480226 Received 13 August 2024 Accepted 21 October 2024 Published 31 October 2024 Volume 12 - 2024 Edited by Ting Li, Southern Medical University, China Reviewed by Pawan Kumar Raghav, University of California, San Francisco, United States Xiaolei Li, University of Pennsylvania, United States Updates Copyright 2024 Shi, Ding, Sun, Lv, Wang, Ma, Lu, Yu, Li and Wang
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