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Our findings turn the spotlight onto GPX4-restricted oxidative processes, which determine the competence of the epithelium to cope with environmental cues that inevitably occur on mucosal surfaces
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The fluorescence intensity was recorded with continuous stirring every 30 sec for at least 5 min at 37 C in an FP-8500 spectrofluorometer (Jasco, Tokyo, Japan) with a fixed emission wavelength at 510 nm
Ethics statement This study was approved by the Institutional Review Board (IRB) of Severance Hospital, Seoul, Republic of Korea (IRB number 4-2016-0901) and, when required, written informed consent was obtained from patients at the time of blood sampling
In this article, well discuss the cellular functions of glutathione, its different forms, and its applications in scientific research
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