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(7) Complex II: Complex II (succinate dehydrogenase, SDH) is an FAD-dependent enzyme embedded in the mitochondrial inner membrane that oxidizes succinate to fumarate as part of the TCA cycle while transferring the resulting electrons through FAD and a series of ironsulfur clusters to ubiquinone (CoQ 10 ), reducing it to ubiquinol (CoQ 10 H 2 ) 74
Glutathione/glutathione disulfide (GSH/GSSG) ratio and Nicotinamide adenine dinucleotide phosphate NADPH/NADP+ ratio were measured using GSH/GSSG Assay Kit (S0053, Beyotime) and NADP/NADPH Quantification Kit (S0179, Beyotime) respectively
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