805 Similarly, GCN2 functions as a metabolic checkpoint by phosphorylating eIF2 during amino acid deprivation, inhibiting protein synthesis while promoting the expression of genes involved in amino acid biosynthesis, thereby modulating T-cell metabolism and immune response
This can cause symptoms such as poor growth, developmental delays, irritability, and failure to thrive in severe cases [*]
437 For young patients with obvious tremors, anticholinergic drugs need to be used cautiously
RER is affected by feeding status, activity, stress, circadian phase, non-steady-state conditions, acid-base balance, and experimental methodology