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For example, contestants from a well-known reality show who lost large amounts of weight through extreme exercise and diet saw their metabolism crash significantly, forcing them to burn hundreds fewer calories than expected just to maintain their new weight
Accessed May 28, 2026.
It is injected under the skin once a week and can be administered in the stomach, thigh, or upper arm
One reason this happens is that the Big E has a hand in modulating two critical hunger-modulating hormones: ghrelin, which can rev up food intake, and leptin, the satiety (aka fullness) hormone
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