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The problem is that this process consumes branched-chain amino acids, specifically leucine, which is the primary driver of muscle protein synthesis

[United States Department of Agriculture, Foreign Agricultural Service Website]

Additionally, intracerebroventricular delivery of Ex-4 has been found to dose-dependently attenuate cue-evoked dopamine activity, further underscoring the direct influence of GLP-1R signaling on neural circuits governing reinforcement and motivation (Konanur et al., 2020)