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For clinical procedures high-end and sophisticated technology may come at a premium price compared to outdated and cheaper technologies
Dose escalation, adherence assumptions, baseline BMI, trial length, rescue medication rules, and discontinuation handling can all change the headline percentage
Interestingly, insulin secretion by Cre+ islets is reduced compared to Cre Ex controls, and is further 2-fold less than controls treated with exendin-4 (Cre Ex + )
It can increase the time it takes for blood to clot, potentially worsening bleeding
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