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MT1 has enhanced half-life and increased affinity for the melanocortin receptor 1 (MC1R), which regulates melanogenesis
You should contact your GP or prescribing clinician if you experience: Persistent or severe nausea and vomiting that prevents adequate fluid or food intake, as this may lead to dehydration Severe or persistent abdominal pain , particularly if localised to the upper abdomen, which could indicate pancreatitis (a rare but serious adverse effect of GLP-1 agonists) Unexplained weight loss beyond what is expected from the medication's therapeutic effect Changes in bowel habit lasting more than a few weeks, including persistent diarrhoea or new-onset constipation Signs of malabsorption , such as pale, floating, foul-smelling stools (steatorrhoea), which may indicate pancreatic insufficiency Symptoms that significantly impair quality of life or prevent you from continuing your medication Right upper quadrant pain, fever, or yellowing of the skin/eyes , which could indicate gallbladder disease (a reported risk with GLP-1 medications) [16] [17] Seek urgent medical attention via NHS 111 or 999 if you develop severe, persistent upper abdominal pain, especially with vomiting
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The key to success is staying engaged with your provider, sharing honest feedback, and making adjustments together as needed
