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KPV, by contrast, is a short tripeptide fragment derived from the alpha-melanocyte stimulating hormone sequence that retains key signaling properties of the parent melanocortin peptide, allowing researchers to investigate inflammatory signaling pathways and epithelial barrier biology in controlled laboratory systems

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65,67 Corticotropin-releasing hormone activates the stress response by stimulating pituitary secretion of adrenocorticotropic hormone (ACTH), which in turn stimulates cortisol release from the adrenal glands

Gastroenterology 123 , 163172 (2002)