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[14] [15] To minimise this risk, the UK SmPC recommends gradual dose titration, starting at 2.5 mg once weekly and increasing every four weeks as tolerated, up to a maximum of 15 mg weekly

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This is the most reliable visual indicator of significant degradation

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Hypoglycemia-related symptoms tend to emerge 2-4 hours after eating, particularly after high-carbohydrate meals that trigger an exaggerated insulin response

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