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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome
The 24-week phase 2b study did not reach statistical significance on its primary weight endpoint, and the developer ended the obesity programme in 2007 [2]
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Neurogastroenterol Motil (2014) 26:115562
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