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22 measured the concentrations of cysteine, GSH, and taurine in 14 healthy subjects and 10 patients with cirrhosis fed either mixed food, nasogastric hyperalimentation with Vivonex (Sandoz Nutrition, Minneapolis, MN), or FreAmine III (McGraw, Irvine, CA) intravenous hyper-alimentation
This progressive change highlights the cumulative benefits of consistent treatment
In an antimicrobial context, this could tentatively be interpreted as ApoE playing a role in coordinating metal ions to alter A aggregation dynamics toward increased cytotoxic aggregate formation to increase As antimicrobial efficacy (either alone or in synergy with other AMPs and copper), for which ApoE4 might exert the strongest synergistic AMP effect due to its copper-A interaction and its ability stabilize cytotoxic A oligomers/fibrils (Garai et al., 2014)
J nanobiotechnol (2022) 20(1):179
