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Although the uptake ratios of tumor per kidney in most of the 18 F-labeled exendin-4 probes were reported as less than 1.0 18 , some modifications such as [ 18 F]FPenM-[Cys 40 ]exendin-4 and [ 18 F]FNEM-[Cys 40 ]exendin-4 successfully demonstrated improved uptake ratios of tumor per kidney that were comparable to our PEGylated probe 31,32

Clinical evidence indicates that injectable options can help patients lose 15% to 20% of their total body weight over a sustained period, while oral forms typically yield a more modest 5% to 10% reduction

This usually fades within a few hours