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Shibuya et al., 2009) and non-CG methylation (Inoue and Oishi, 2005) could have a biological relevance, single-base analysis of genome-wide DNA methylation is of critical importance

According to the AIE mechanism, the fluorescence of these dyes can be turned on/off if the analyte can alter the aggregation behavior (solubility) or the intramolecular motions of the fluorescent species 55,56