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In the case of benzodiazepines, sudden cessation after chronic use may result in dreamless sleep being replaced by insomnia and nightmares

Of the 119 inter-molecular NOE restraints, only 20 NOEs could be assigned unambiguously (Supplementary Note 2)

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Optimise general joint health through evidence-based lifestyle measures: Maintain a healthy weight to reduce mechanical stress on weight-bearing joints Engage in regular low-impact exercise such as swimming, cycling, or walking to maintain joint mobility and strengthen supporting muscles Apply heat or cold therapy as appropriateheat for stiffness, cold for acute inflammation Follow a balanced diet with plenty of fruits, vegetables, and whole grains