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Retatrutide's potency also comes with a dose-dependent side-effect profile predominantly gastrointestinal and the deepest appetite suppression of the class, which is the very thing that can drive protein too low
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This is reflected in the FDA granting survodutide Breakthrough Therapy designation specifically for MASH, an acknowledgment that the drug addresses an unmet medical need in a way existing treatments do not
Some people also use it to prevent migraines
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