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281 Melatonin inhibits the stress effect of ER through the melatonin receptors type 1B (MT2)/cAMP/protein kinase A (PKA)/inositol-requiring enzyme 1 (IRE1) pathway, reducing hepatic ferroptosis in MAFLD

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In one landmark trial, adults without diabetes who took the highest weekly dose lost an average of 20.9 percent of their body weight over 72 weeks, compared with 3.1 percent on placebo, and more than half reached at least a 20 percent reduction (SURMOUNT-1 trial, New England Journal of Medicine, 2022)

Mydlarz LD, Palmer CV (2011) The presence of multiple phenoloxidases in Caribbean reef-building corals