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Key findings from this 48-week, dose-ranging study of 338 adults with obesity: Participants receiving the highest dose (12 mg weekly) lost an average of 24.2% of their body weight in 48 weeks At the 12 mg dose, 100% of participants lost at least 5% of their body weight Approximately 83% of participants on the highest dose lost 15% or more of body weight The weight loss trajectory had not plateaued at 48 weeks, suggesting even greater weight loss with continued treatment To put these numbers in context, here is how retatrutides Phase 2 data compares to the landmark trials of existing medications: The fact that retatrutide achieved the highest percentage of weight loss in the shortest timeframe is what has researchers and patients so excited
130 NeumillerJ
The dosing for Ozempic typically peaks at 2.0 mg per week
Rats were randomly divided into a normal control group (group A1, A2-low dose and A3-high dose) and high-altitude model groups (group B, C-low dose and D-high dose) with 20 rats in each group
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