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Beyond its well established sensory and analgesic properties, capsaicin enhances sympathetic activity and stimulates thermogenesis in brown and beige adipose tissue as well as skeletal muscle via TRPV1 activation-induced Ca 2+ dependent signaling cascades, leading to increased whole-body energy expenditure, reduced adiposity, and improved lipid profiles (57)
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Men face a much higher risk than women This does not, however, fully explain why a drug that is broadly beneficial for heart health and blood sugar control might have such a specific harmful effect on eyesight
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