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Glucagon-Like Peptide-1 Receptor AgonistAssociated Adverse Events Gastrointestinal Adverse Events Gastrointestinal adverse effects, most notably nausea, vomiting, diarrhoea, and constipation, are the most frequently reported safety events associated with GLP-1 receptor agonists and represent a leading cause of treatment discontinuation in clinical trials of obesity and type 2 diabetes
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