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The compounds listed in Table S4, tested at various times and at concentrations with statistically significant effect, induce eryptosis dependent on calcium, ceramide, and ROS
Since high miR-125b expression in NSCLC tumors is strongly associated with a decrease in overall and recurrence-free patient survival, and is significantly correlated with low IGFBP-3 expression, this study points to miR-125b-dependent IGFBP-3 downregulation as a contributory factor in NSCLC [55]
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