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Temporary telogen effluvium may occur secondary to rapid weight loss, caloric restriction, or significant metabolic changes similar observations have been reported with other obesity therapies and are typically reversible

Finally, genetic modification of cells to increase PC1/3 expression has been shown to improve glucose regulation in animal models (21, 22)

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Options include increasing concentration, adding microneedling, incorporating other treatments like minoxidil, or switching to GHK-Cu to test whether the alternative copper peptide produces better individual response