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In vivo and in vitro studies have shown that Klotho enhances renal tubular cell autophagy and contributes to kidney protection via activation of AMPK and ERK and contributes to kidney protection pathways
In addition, NNMTi promotes the secretion of antiinflammatory lipids (such as PAHSA) by adipocytes, further relieving adipose inflammation and improving metabolic function
Potential for long-term maintenance: The once-weekly dosing format may improve compliance compared to daily medications
Douglass, J
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