As a result, folate deficiency can lead to many neuropsychiatric manifestations, such as depression, alterations in neurotransmitter function, DNA damage, as well as being associated with the development of autism spectrum disorders in children, neural tube irregularity and brain development defects (4, 19, 20, 22, 30, 66, 68, 69)
Qu ZQ, Zhou Y, Zeng YS, Lin YK, Li Y, Zhong ZQ, Chan WY (2012) Protective effects of a Rhodiolacrenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat
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However, in vitro, evidence suggests that hyperglycemia, a primary metabolic feature of T2DM, can lead to impaired GLP-1 secretion and L-cell differentiation