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Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis

(91) demonstrated that nuciferine inhibits ferroptosis via the SOX2-mediated SLC7A11/GPX4 signaling axis, thereby protecting ovarian granulosa cells from androgen-induced damage

Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches

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