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In women with insulin resistance, like those with PCOS or prediabetes, GLP-1 medications improve glucose control, which supports weight loss
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The most successful outcomes combine pharmaceutical intervention with lasting behavioral changes that persist beyond treatment
Further work showed that GLP-1R-expressing ventral hippocampal neurons are monosynaptically connected to the medial prefrontal cortex (mPFC), and the suppression of food intake and motivated behaviors by intra-ventral hippocampal administration of exendin-4 is lost with their inhibition or antagonism of NMDARs [172]
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