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A ratio above 0.20 mcg/nmol has been associated with acromegalic pathophysiology in some research contexts, though no validated clinical threshold exists specifically for this calculation [1]
However, synthetic folic acid supplements are difficult for your body to transform into the natural, active form of folate that does these jobs (1)
Thus, no evidence exists to support the application of vitamin D supplementation for IBS treatment as no clear relationship between vitamin D levels and symptomology has been demonstrated
Stayer-Wilburn, O
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