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Raps, A
Clinical Research: A study in The Journal of Clinical and Aesthetic Dermatology showed that patients using polypodium orally in combination with topical sunscreens had a marked improvement in melasma lesions, with a decrease in pigmentation intensity
However, clinical trial data on this specific combination in humans remains sparse, and most evidence comes from mechanism-of-action studies and case reports rather than large randomized controlled trials
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