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Animal studies have demonstrated that MSM can alleviate knee joint and cartilage degeneration in mice, reduce cartilage damage in rheumatoid arthritis rats, protect the articular cartilage surface in rabbits with osteoarthritis, and prevent cartilage erosion in the meniscus of sheep [5155]

In our recent studies, we have identified a different inhibition mechanism of TGR in which an inhibitor binds non-covalently at the so-called doorstop pocket interfering with enzyme function 33,34

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