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HUA treatment options targeting transporters 3.1 Drug research targeting HUA-related transport proteins When urate is excreted from the kidneys, approximately 90% of urate filtered by the renal glomeruli is reabsorbed back into the bloodstream, with only 10% being excreted by the kidneys
The severity of this initial inflammatory hit often correlates with downstream organ injury (for instance, peak IL-6 after cardiac surgery is a strong predictor of postoperative atrial fibrillation and AKI)
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