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Typically, dose escalation begins at 0.25mg weekly and increases incrementally to a maximum of 2.4mg if well-tolerated
Gastrointestinal side effects, including constipation, are a primary reason some patients may need to delay dose escalation or temporarily reduce their dose
Clinicians also closely monitor symptoms and maintain quick access to advice during the transition period, so adjustments can be made if appetite or glucose control worsens
Un anlisis detallado de las curvas de eventos con una separacin de las curvas despus de 12 a 18 meses, as como el hecho de que se reducen los resultados primarios y secundarios como infarto de miocardio, accidente cerebrovascular, muerte cardiovascular y revascularizacin, sugieren que los efectos beneficiosos de Los AR GLP-1 estn mediados por una reduccin de los eventos relacionados con la aterosclerosis
