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1983, Effects of variation in the dietary supply of cysteine and methionine on liver concentration of glutathione and active sulfate (PAPS) and serum levels of sulfate, cystine, methionine and taurine: relation to the metabolism of acetaminophen, J
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In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig
This endogenous activation provides sustained cellular protection compared to direct free radical scavenging by exogenous antioxidants
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