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cAMP generated by activation of the GLP-1 receptor may also influence the exocytotic process directly, and this process has been estimated to account for up to 70% of the entire secretory response (124)
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The direct interaction between MAPKAPK2 and Nrf2 remains to be confirmed through luciferase reporter or co-immunoprecipitation assays, and the association between MAPKAPK2 expression and promoter methylation should be validated using bisulfite sequencing or methylation array analyses
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