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FDA labels for these medications include warnings about the risk of dehydration and acute kidney injury, particularly during episodes of significant gastrointestinal illness
189,190,191 Activation of GLP-1R leads to the production of cAMP (cyclic Adenosine Monophosphate), which is achieved by activating Adenylyl Cyclase (AC)
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Thus, we evaluated GEP44-mediated GLP-1R and Y2-R internalization and compared the results to those obtained using Ex-4 or PYY 3-36 , respectively
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