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[78] found that Lira inhibited proprotein convertase subtilisin/kexin type 9 (PCSK9) expression in HepG2 cells and db/db mice through hepatocyte nuclear factor 1 (HNF1)-dependent mechanism, and may inhibit LDLR expression in db/db mice through PCSK9 independent pathway, and ultimately reduce liver cholesterol accumulation
International Journal of Molecular Sciences, September 2018, pages 1-44 2
Step 3: The Showstopper (Optional) For some patients, a grand finale may be in order
Arm melanomas frequently appear on sun-exposed skin
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