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Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I: SAVOR-TIMI 53 Steering Committee and Investigators

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Additionally, HAE independently disrupts complement pathways (both classical and lectin), impairing the clearance of apoptotic cells and immune complexes, thereby increasing exposure to autoantigens and the risk of autoimmunity [3]