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Moreover, FOXO4-DRI was used to selectively induce apoptosis of senescent fibroblasts in both keloid fibroblast and organ culture senescent models, showing potential as a treatment that targets the senescence and apoptosis resistance observed in keloid fibroblasts
E.FerraiuoloL.Haidet-PhillipsA
Cynomolgus monkeys were administered subcutaneously with 0.02, 0.05, and 0.1 mg/kg of Compound A
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