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Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells
This was one of the most common side effects in studies of the drug
Plus, it may also cause primary pulmonary hypertension or valvular heart disease, which is why people with existing or previous cardiovascular conditions should avoid it
Biochemistry, pathophysiology, and regulation of linear ubiquitination: intricate regulation by coordinated functions of the associated ligase and deubiquitinase
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