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In Phase 3 studies: Participants without diabetes taking orforglipron lost approximately 9% to 10% of body weight over roughly 36 to 40 weeks Participants with type 2 diabetes generally lost around 7% to 8% By comparison, Wegovy's landmark STEP trials reported approximately 14.9% average weight loss over 68 weeks
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What we found was a pretty significant reduction in cravings at a much lower dose than the general population tends to be on, particularly for weight loss, he says
References: Science Direct: Anhedonia in depression: biological mechanisms and computational models Clinical Psychopharmacology and Neuroscience: Anhedonia and Depressive Disorders Frontiers: A Delphi consensus on clinical features, diagnosis and treatment of major depressive disorder patients with anhedonia amongst psychiatrists in the Asia-Pacific Plos One: Prevalence and burden of anhedonia among patients with major depressive disorder in South Korea: A cross-sectional, observational study Frontiers: Association of Cognitive Impairment With Anhedonia in Patients With Schizophrenia MDPI: Can Anhedonia Be Considered a Suicide Risk Factor
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