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Their stable architecture reroutes PD-L1 from its normal recycling pathway to lysosomal degradation, sustaining checkpoint suppression for over 72 h and restoring T-cell cytotoxicity far more durably than conventional antibodies [19]

Favorable reductions in ROS levels were restricted to the hippocampus, posterior cortex, and cerebellum, whereas other brain regions showed heterogeneous or unfavorable redox responses, including alterations in antioxidant enzyme activity

(Baltimore Md) 63 (6), 19872003

Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment