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However, a favorable effects of DPP-4 inhibitors on albuminuria has not been a consistent finding in clinical trials [87], possibly because potentiation of SDF-1 in podocytes may aggravate proteinuria, and thus, may oppose the benefits expected from glycemic control [28]

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Lifestyle considerations include: Eating slowly and stopping when comfortably full Avoiding high-fat meals that may worsen nausea Timing meals consistently throughout the day Monitoring blood sugar if at risk for hypoglycemia Sleep quality often improves with weight loss, particularly for those with obstructive sleep apnea (OSA)

Cardiovasc Diabetol 2023;22(1)