(9, 11) At the metabolic level, the signaling cascades that regulate bone metabolism offer some explanation for the obesity paradox
The results of these experiments demonstrate that in spite of the role of mTORC1 in the control of energy metabolism, as evidenced by a significant reduction of overall glucose consumption and uptake following Rapamycin treatment
Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz C, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrn E (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Research on peptides for hormone balance explores how these systems interact and how targeted interventions can help restore equilibrium