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It binds to melanocortin receptors in the brain, particularly MC4, and triggers dopamine release in the brain pathways tied to sexual motivation and arousal
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Importantly, these medications carry a boxed warning about thyroid C-cell tumors observed in rodent studies and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
doi: 10.1016/j.jocn.2017.06.009 9 OMahonySMClarkeGDinanTGCryanJF
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