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Sources Eli Lilly press release TRIUMPH-1 Phase 3 topline results, May 21, 2026 Eli Lilly press release TRIUMPH-4 Phase 3 trial results, December 2025 Eli Lilly press release TRANSCEND-T2D-1 topline results, March 19, 2026 Bajaj HS et al

On the other hand, compounded drugs are not subject to the same kind of regulation and do not require FDA approval

Mast Cell Activation Syndrome (MCAS) is when mast cells become overly responsive and easily triggered and therefore, release a lot of histamine

Dehydration is a related concern, as both reduced fluid intake (due to appetite suppression) and increased fluid losses (from gastrointestinal side effects) can contribute to volume depletion