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These findings provide clinicians and patients with important real-world evidence to inform treatment decisions, while underscoring the need for continued patient monitoring
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Appropriate reasons to discuss discontinuation include achieving your weight loss goals and wanting to attempt weight maintenance without medication, experiencing intolerable side effects that don't improve with dose adjustment or supportive management, financial constraints that make continued treatment unsustainable, planning pregnancy (semaglutide is not recommended during pregnancy and should be discontinued at least two months before conception), or developing contraindications to continued use
39 Afamelanotide is also used off label for vitiligo
