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In a mechanism of action study that aimed to achieve 10% body weight reduction in participants with obesity who were without T2D, tirzepatide was compared to placebo for sleeping and 24-h energy expenditure and respiratory exchange ratio by utilizing metabolic chambers assessed at baseline and after 18 weeks [56]
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doi: 10.3390/ijms23020740 32 McDuffieJRRiggsPACalisKAFreedmanRJOralEADePaoliAMet al
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