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Pharmacotherapy, including the GLP-1 receptor agonists, have also revolutionized obesity management. With limited head-to-head comparisons between bariatric surgery, bariatric endoscopy and GLP-1RAs, Velji-Ibrahim and colleagues conducted a systematic review and network meta-analysis to contrast the efficacy and safety of the three options

Patients who have undergone gastric banding should be aware of the following signs that may indicate falling B12 levels and warrant prompt blood testing: Neurological symptoms: Tingling, numbness, or 'pins and needles' in the hands or feet Difficulty with balance or coordination Memory problems, difficulty concentrating, or 'brain fog' Mood changes, including low mood or irritability Haematological symptoms: Persistent fatigue or weakness disproportionate to activity levels Breathlessness on mild exertion Pallor or a slightly yellowish tinge to the skin Other indicators: A sore, smooth, or inflamed tongue (glossitis) Mouth ulcers occurring frequently It is important to recognise that some of these symptoms particularly fatigue and low mood are non-specific and may overlap with other post-operative nutritional deficiencies, such as iron or vitamin D deficiency

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These GLP-1 receptor agonists have helped many people achieve significant weight loss