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You are not swallowing a pill on an empty stomach every morning

Historically, this increased insulin response mediated by GLP-1 and GIP had been attributed to factors termed incretins (derived from incretion, a term used at that time to refer to a secretion that remains inside the body), hence the name incretin effect is still used today to describe the rise in insulin mediated by the action of these hormones

A key safety advantage is the absence of cortisol and prolactin elevation, which are associated with muscle wasting, fat gain, immune suppression (cortisol), and sexual dysfunction (prolactin) when chronically elevated

Any appetite-related changes are secondary: as sleep improves, energy returns, and body composition shifts, patients naturally feel more motivated to support those changes with better nutrition