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SKU: 11005972990

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doi: 10.1074/jbc.M005340200 30 PochiniLGalluccioMConsoleLScaliseMEberiniIIndiveriC

This modification impacts transcriptional regulation and extends to non-histone proteins, thereby regulating enzyme activities (11,12)

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug

The anti-cancer properties of biguanides are displayed through several mechanisms of action, including the activation AMPK pathway with the consequent inhibition of mTOR and reduction of several pro-tumorigenic effects including cell proliferation and production of inflammatory mediators (Seyfried et al., 2014