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1, the association of genetically predicted l-carnitine with CAD was consistent in different data sources (CARDIoGRAMplusC4D, the UK Biobank and FinnGen)
All GLP-1 receptor agonists and tirzepatide carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
One-time endoscopic examination in this high-risk group can identify Barretts metaplasia, a precursor to adenocarcinoma
However, slower gastric transit may: Reduce tolerance for large meals Increase early satiety Contribute to nausea in susceptible individuals The primary nutritional impact therefore arises from intake reduction rather than impaired absorption
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